RT Journal Article
SR Electronic
T1 BRCA1 and PALB2 in a Messy Breakup
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 4044
OP 4045
DO 10.1158/0008-5472.CAN-20-2731
VO 80
IS 19
A1 Her, Joonyoung
A1 Bunting, Samuel F.
YR 2020
UL http://cancerres.aacrjournals.org/content/80/19/4044.abstract
AB Mutations in the BRCA1 gene cause an extremely high lifetime risk of breast and ovarian cancer, but the exact mechanism by which the BRCA1 protein acts to prevent cancer onset remains unclear. In this edition of Cancer Research, Park and colleagues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1. This change prevents BRCA1 from interacting with PALB2 (partner and localizer of BRCA2), causing rapid cancer onset and a loss of blood cells similar to Fanconi anemia.See related article by Park et al., p. 4172