PT  - JOURNAL ARTICLE
AU  - Hosokawa, Masuo
AU  - Okayasu, Takeshi
AU  - Ikeda, Kohichiro
AU  - Katoh, Hiroyuki
AU  - Suzuki, Yasuhiro
AU  - Kobayashi, Hiroshi
TI  - Alteration of Immunogenicity of Xenogenized Tumor Cells in Syngeneic Rats by the Immune Responses to Virus-associated Antigens Produced on Immunizing Cells
DP  - 1983 May 01
TA  - Cancer Research
PG  - 2301--2305
VI  - 43
IP  - 5
4099  - http://cancerres.aacrjournals.org/content/43/5/2301.short
4100  - http://cancerres.aacrjournals.org/content/43/5/2301.full
SO  - Cancer Res1983 May 01; 43
AB  - A strong transplantation resistance to a fibrosarcoma (KMT-17) is induced in syngeneic Wistar King Aptekman/Hok rats after a single s.c. immunization with Friend virus-infected (xenogenized) viable KMT-17 cells. The resistance induced by the repeated immunizations with irradiated Friend virus-infected KMT-17 cells, however, was unexpectedly weaker when compared with that induced by irradiated KMT-17 cells. The immunogenicity of tumor-associated antigen on xenogenized Friend virus-infected KMT-17 cells was correlated with their shortened survival time in the peritoneal cavity after i.p. inoculation, especially in rats preimmunized with xenogenized tumor cells. Furthermore, xenogenized tumor cells producing a medium amount of virus-associated antigen (VAA) but not those producing a large amount of VAA showed an augmented immunogenicity even in normal rats. On the other hand, the tumor-associated antigen immunogenicity was augmented by immunization with xenogenized tumor cells which expressed a relatively small amount of VAA in rats presensitized with VAA. These findings indicate that the immunogenicity of xenogenized tumor cells is augmented by the middle-grade immune responses to VAA produced on xenogenized tumor cells. ©1983 American Association for Cancer Research.