RT Journal Article
SR Electronic
T1 Correlation of Dietary Aflatoxin B<sub>1</sub> Levels with Excretion of Aflatoxin M<sub>1</sub> in Human Urine
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 1848
OP 1852
VO 47
IS 7
A1 Zhu, Jia-qi
A1 Zhang, Li-sheng
A1 Hu, X.
A1 Xiao, Y.
A1 Chen, Jun-shi
A1 Xu, Yi-chun
A1 Fremy, J.
A1 Chu, F. S.
YR 1987
UL http://cancerres.aacrjournals.org/content/47/7/1848.abstract
AB Corn and peanut oil (total, 253 samples) were collected from 32 households in Fushui county of the Guangxi autonomous region of the People's Republic of China, where high liver cancer incidence has been reported, every day over a period of 1 week and analyzed for aflatoxin B1 (AFB). A total of 252 urine samples were collected simultaneously from the residents in the households which were shown to have consumed AFB and were analyzed for aflatoxin M1 (AFM) by a competitive direct enzyme-linked immunosorbent assay. A good correlation between total dietary AFB intake and total AFM excretion in human urine was observed during a 3-day study. A regression equation of 0.143 plus 0.0135 multiplied by the amount of AFB consumed was observed. Between 1.23 and 2.18% of dietary AFB was found to be present as AFM in human urine. A good correlation was also observed between the AFB concentration in corn and the AFM concentration in human urine. The results suggest that analysis of AFM in urine by enzyme-linked immunosorbent assay could be used as an index for human exposure of AFB in an extensive epidemiological study. ©1987 American Association for Cancer Research.