RT Journal Article
SR Electronic
T1 Chromosomal Translocations with Specific Breakpoints in Asbestos-induced Rat Mesotheliomas
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6455
OP 6461
VO 48
IS 22
A1 Libbus, Bisharah L.
A1 Craighead, John E.
YR 1988
UL http://cancerres.aacrjournals.org/content/48/22/6455.abstract
AB Cytogenetic analysis was conducted on cells of 15 rat mesotheliomas induced in rats by the i.p. inoculation of crocidolite or chrysotile asbestos. These tumor cells were diploid, triploid, or tetraploid. All tumor lines exhibited aneuploidy and marker chromosomes. Loss of at least one copy of the X chromosome was observed in each of the tumors analyzed, and loss of copies of chromosomes 8, 16, 20, or 18 characterized at least six of the tumors. Translocations were observed in 12 tumors, with six chromosome rearrangements present in at least two different tumors. However, the breakpoints were not always identical. On the other hand, translocations involving chromosomes 5, 10, and 13 exhibited repeated breakage at the same loci. Such specific and repetitive translocations may be involved in the process of asbestos-induced tumor development. ©1988 American Association for Cancer Research.