PT  - JOURNAL ARTICLE
AU  - Bjelfman, Catarina
AU  - Hedborg, Fredrik
AU  - Johansson, Irja
AU  - Nordenskjöld, Magnus
AU  - Påhlman, Sven
TI  - Expression of the Neuronal Form of pp60<sup>c-src</sup> in Neuroblastoma in Relation to Clinical Stage and Prognosis
DP  - 1990 Nov 01
TA  - Cancer Research
PG  - 6908--6914
VI  - 50
IP  - 21
4099  - http://cancerres.aacrjournals.org/content/50/21/6908.short
4100  - http://cancerres.aacrjournals.org/content/50/21/6908.full
SO  - Cancer Res1990 Nov 01; 50
AB  - The expression of the protooncogene c-src has been studied in specimens of childhood tumors with special reference to neuroblastoma and other tumors of neuronal origin. For comparison c-src gene expression was studied in seven neuroblastoma and neuroepithelioma cell lines. The structurally distinct neuronal product of the gene, pp60c-srcN, expressed during normal development in neuroblasts and neurons, was identified by immunoblotting technique together with the fibroblast form, pp60c-src. While pp60c-src was found in most tumors studied, the neuronal form was restricted to neuroblastomas (23 of 27) and retinoblastomas (3 of 3) and could not be detected in the other childhood tumors. A dominance of the neuronal form, pp60c-srcN, was exclusively found in the infant cases of neuroblastoma (9 of 12), estimated to have good prognosis. These results indicate that pp60c-srcN might be a diagnostic marker in primitive childhood tumors. When expressed in higher amounts than pp60c-src, pp60c-srcN may be a positive prognostic marker in neuroblastoma, especially useful in the evaluation of infants. In addition, lack of pp60c-srcN seems to be incompatible with low stage neuroblastoma. ©1990 American Association for Cancer Research.