PT  - JOURNAL ARTICLE
AU  - Marth, Christian
AU  - Müller-Holzner, Elisabeth
AU  - Greiter, Evi
AU  - Cronauer, Marcus V.
AU  - Zeimet, Alain G.
AU  - Doppler, Wolfgang
AU  - Eibl, Brigitte
AU  - Hynes, Nancy E.
AU  - Daxenbichler, Günter
TI  - γ-Interferon Reduces Expression of the Protooncogene c-<em>erb</em>B-2 in Human Ovarian Carcinoma Cells
DP  - 1990 Nov 01
TA  - Cancer Research
PG  - 7037--7041
VI  - 50
IP  - 21
4099  - http://cancerres.aacrjournals.org/content/50/21/7037.short
4100  - http://cancerres.aacrjournals.org/content/50/21/7037.full
SO  - Cancer Res1990 Nov 01; 50
AB  - The overexpression of the protooncogene c-erbB-2 (HER-2/neu) in ovarian and mammary carcinoma is an important indicator for a bad prognosis. In this study we demonstrate that, in three of four ovarian carcinoma cell lines, there is a γ-interferon-mediated reduction in c-erbB-2 specific protein, and this effect was found to correlate with the antiproliferative action. It is interesting to note that there is no relation between the absolute amount of c-erbB-2 protein expressed and the sensitivity of the ovarian carcinoma cells for an antiproliferative activity of γ-interferon. Other chemotherapeutic agents did not affect c-erbB-2 expression, although they inhibited the proliferation. The oncogene expression was lowered only in the ovarian carcinoma cell lines and not in three γ-interferon-sensitive human breast cancer cell lines. Expression of the oncogene c-erbB-2 is the leading prognostic factor in ovarian cancer. Its modulation might represent a mechanism by which γ-interferon inhibits cell proliferation. ©1990 American Association for Cancer Research.