RT Journal Article SR Electronic T1 γ-Interferon Reduces Expression of the Protooncogene c-erbB-2 in Human Ovarian Carcinoma Cells JF Cancer Research JO Cancer Res FD American Association for Cancer Research SP 7037 OP 7041 VO 50 IS 21 A1 Marth, Christian A1 Müller-Holzner, Elisabeth A1 Greiter, Evi A1 Cronauer, Marcus V. A1 Zeimet, Alain G. A1 Doppler, Wolfgang A1 Eibl, Brigitte A1 Hynes, Nancy E. A1 Daxenbichler, Günter YR 1990 UL http://cancerres.aacrjournals.org/content/50/21/7037.abstract AB The overexpression of the protooncogene c-erbB-2 (HER-2/neu) in ovarian and mammary carcinoma is an important indicator for a bad prognosis. In this study we demonstrate that, in three of four ovarian carcinoma cell lines, there is a γ-interferon-mediated reduction in c-erbB-2 specific protein, and this effect was found to correlate with the antiproliferative action. It is interesting to note that there is no relation between the absolute amount of c-erbB-2 protein expressed and the sensitivity of the ovarian carcinoma cells for an antiproliferative activity of γ-interferon. Other chemotherapeutic agents did not affect c-erbB-2 expression, although they inhibited the proliferation. The oncogene expression was lowered only in the ovarian carcinoma cell lines and not in three γ-interferon-sensitive human breast cancer cell lines. Expression of the oncogene c-erbB-2 is the leading prognostic factor in ovarian cancer. Its modulation might represent a mechanism by which γ-interferon inhibits cell proliferation. ©1990 American Association for Cancer Research.