RT Journal Article
SR Electronic
T1 Acetylator Polymorphism in Human Colorectal Carcinoma
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 2098
OP 2100
VO 51
IS 8
A1 Ladero, José M.
A1 González, José F.
A1 Benítez, Julio
A1 Vargas, Emilio
A1 Fernández, María J.
A1 Baki, Walid
A1 Diaz-Rubio, Manuel
YR 1991
UL http://cancerres.aacrjournals.org/content/51/8/2098.abstract
AB Acetylator phenotype has been determined using sulfamethazine in 109 patients histologically diagnosed with colorectal carcinoma (resected in 74 patients by the time of the study) and in 96 age-matched controls. Fifty-five % of patients and 58.3% of controls were classified as slow acetylators (χ2 = 0.11, not significant). No differences were observed in the distribution of acetylator phenotype when analyzing separately male and female, surgically treated and untreated, and colonic and rectal carcinoma patients. We conclude that acetylator polymorphism is not a genetic trait related to the risk of developing colorectal carcinoma in human beings. ©1991 American Association for Cancer Research.