RT Journal Article
SR Electronic
T1 Evidence for the Involvement of a Potential Second Tumor Suppressor Gene on Chromosome 17 Distinct from <em>p53</em> in Malignant Astrocytomas
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6716
OP 6721
VO 52
IS 23
A1 Saxena, Abha
A1 Clark, W. Craig
A1 Robertson, James T.
A1 Ikejiri, Barbara
A1 Oldfield, Edward H.
A1 Ali, Iqbal Unnisa
YR 1992
UL http://cancerres.aacrjournals.org/content/52/23/6716.abstract
AB Molecular analysis of malignant astrocytomas demonstrated three distinct groups of tumors with chromosome 17p abnormalities, which include (a) deletion of the p53 locus (17p13.1) and mutations in the remaining allele, (b) deletion of the p53 locus but no detectable mutations in the remaining allele, and (c) deletions not including the p53 locus but mutations in one of the alleles. Furthermore, deletion mapping analysis demonstrated allelic loss of genes distal to D17S28/D17S5 markers (17p13.3) in group C tumors. The loss of heterozygosity of genes on chromosome 17 without detectable mutation (group B) or deletion (group C) in the p53 gene implies the presence of a second tumor suppressor gene in the telomeric region of 17p, the homozygous functional inactivation of which may play a role, either alone or in conjunction with p53, in the initiation and/or progression of astrocytic neoplasms. ©1992 American Association for Cancer Research.