RT Journal Article
SR Electronic
T1 Human Gastric Carcinogenesis: A Multistep and Multifactorial Process—First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6735
OP 6740
VO 52
IS 24
A1 Correa, Pelayo
YR 1992
UL http://cancerres.aacrjournals.org/content/52/24/6735.abstract
AB Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with Helicobacter pylori. The intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. The final stages have been linked with the supply of β-carotene and with excessive salt intake. Nitrosating agents are candidate carcinogens and could originate in the gastric cavity or in the inflammatory infiltrate. ©1992 American Association for Cancer Research.