RT Journal Article
SR Electronic
T1 The Incidence of <em>p53</em> Mutations Increases with Progression of Head and Neck Cancer
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 4477
OP 4480
VO 53
IS 19
A1 Boyle, Jay O.
A1 Hakim, John
A1 Koch, Wayne
A1 Riet, Peter van der
A1 Hruban, Ralph H.
A1 Roa, R. Arturo
A1 Correo, Russell
A1 Eby, Yolanda J.
A1 Ruppert, J. Michael
A1 Sidransky, David
YR 1993
UL http://cancerres.aacrjournals.org/content/53/19/4477.abstract
AB To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carcinoma in situ lesions. The incidence of p53 mutations in noninvasive lesions was 19% (7/37) and increased to 43% (28/65) in invasive carcinomas. These data suggest that p53 mutations can precede invasion in primary head and neck cancer. Furthermore, the spectrum of codon hotspots is similar to that seen in squamous carcinoma of the lung and 64% of mutations are at G nucleotides, implicating carcinogens from tobacco smoke in the etiology of head and neck squamous carcinoma. ©1993 American Association for Cancer Research.