PT  - JOURNAL ARTICLE
AU  - Han, Hye-Jung
AU  - Yanagisawa, Akio
AU  - Kato, Yo
AU  - Park, Jae-Gahb
AU  - Nakamura, Yusuke
TI  - Genetic Instability in Pancreatic Cancer and Poorly Differentiated Type of Gastric Cancer
DP  - 1993 Nov 01
TA  - Cancer Research
PG  - 5087--5089
VI  - 53
IP  - 21
4099  - http://cancerres.aacrjournals.org/content/53/21/5087.short
4100  - http://cancerres.aacrjournals.org/content/53/21/5087.full
SO  - Cancer Res1993 Nov 01; 53
AB  - To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosomes 2, 3, and 17. A significantly high incidence of genetic instability was observed in pancreatic (6 of 9 tumors) and gastric cancers (22 of 57 cases). In other types of carcinoma, the incidence of replication error-positive cases was relatively low (3–16%). Among gastric carcinomas, significantly more replication error-positive cases were observed in the poorly differentiated types (16 of 25 cases) than in well differentiated types (3 of 18) (P = 0.0023 by Fisher's exact test). Our results suggested that genetic instability is likely to play an important role in development of pancreatic and gastric cancers, particularly poorly differentiated adenocarcinomas. ©1993 American Association for Cancer Research.