PT  - JOURNAL ARTICLE
AU  - Davies, Bernard
AU  - Waxman, Jonathan
AU  - Wasan, Harpret
AU  - Abel, Paul
AU  - Williams, Gordon
AU  - Krausz, Thomas
AU  - Neal, David
AU  - Thomas, David
AU  - Hanby, Andrew
AU  - Balkwill, Frances
TI  - Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion
DP  - 1993 Nov 15
TA  - Cancer Research
PG  - 5365--5369
VI  - 53
IP  - 22
4099  - http://cancerres.aacrjournals.org/content/53/22/5365.short
4100  - http://cancerres.aacrjournals.org/content/53/22/5365.full
SO  - Cancer Res1993 Nov 15; 53
AB  - We have used quantitative zymography to measure levels of the type IV collagenases matrix metalloproteinase (MMP)-9 and MMP-2 in 42 biopsies of transitional cell carcinoma and in 7 biopsies of normal bladder. Mean levels of MMP-9 were significantly higher in tumor compared with normal samples (P = 0.08). Levels of MMP-9 and active MMP-2 increased with tumor grade (test for trend, P = 0.002 and P = 0.05, respectively). Levels of MMP-9 and activated MMP-2 were also higher in invasive tumors than in superficial ones (P = 0.001 and P = 0.008, respectively). In situ hybridization studies showed that the mRNAs for both MMP-2 and MMP-9 were located chiefly in the stroma rather than epithelial tumor cells and were concentrated at the interface between the two tissues. ©1993 American Association for Cancer Research.