PT  - JOURNAL ARTICLE
AU  - Peltomäki, Päivi
AU  - Lothe, Ragnhild A.
AU  - Aaltonen, Lauri A.
AU  - Pylkkänen, Lea
AU  - Nyström-Lahti, Minna
AU  - Seruca, Raquel
AU  - David, Leonor
AU  - Holm, Ruth
AU  - Ryberg, David
AU  - Haugen, Aage
AU  - Brøgger, Anton
AU  - Børresen, Anne-Lise
AU  - de la Chapelle, Albert
TI  - Microsatellite Instability Is Associated with Tumors That Characterize the Hereditary Non-Polyposis Colorectal Carcinoma Syndrome
DP  - 1993 Dec 15
TA  - Cancer Research
PG  - 5853--5855
VI  - 53
IP  - 24
4099  - http://cancerres.aacrjournals.org/content/53/24/5853.short
4100  - http://cancerres.aacrjournals.org/content/53/24/5853.full
SO  - Cancer Res1993 Dec 15; 53
AB  - Microsatellite instability implying multiple replication errors (RER+ phenotype) characterizes a proportion of colorectal carcinomas, particularly those from patients with the hereditary non-polyposis colorectal carcinoma syndrome. We studied the incidence of microsatellite instability in more than 500 sporadic tumors representing 6 different types of cancer. Apart from colorectal carcinoma [see the paper by Lothe et al. (Cancer Res., 53: 5849–5852, 1993)] the RER+ phenotype was found in 18% (6 of 33) of gastric carcinomas and 22% (4 of 18) of endometrial carcinomas. In contrast, no evidence of this abnormality was detected in cancers of the lung (N = 85), breast (N = 84), and testis (N = 86). Importantly, the first three cancers, as opposed to the latter three, are characteristic of the hereditary non-polyposis colorectal carcinoma syndrome. These findings suggest that the cancers belonging to the hereditary non-polyposis colorectal carcinoma tumor spectrum may have essential pathogenetic steps in common, including a tendency to multiple replication errors. ©1993 American Association for Cancer Research.