PT  - JOURNAL ARTICLE
AU  - Gordon, Kathleen B.
AU  - Thompson, Curtis T.
AU  - Char, Devron H.
AU  - O'Brien, Joan M.
AU  - Kroll, Stewart
AU  - Ghazvini, Siavash
AU  - Gray, Joe W.
TI  - Comparative Genomic Hybridization in the Detection of DNA Copy Number Abnormalities in Uveal Melanoma
DP  - 1994 Sep 01
TA  - Cancer Research
PG  - 4764--4768
VI  - 54
IP  - 17
4099  - http://cancerres.aacrjournals.org/content/54/17/4764.short
4100  - http://cancerres.aacrjournals.org/content/54/17/4764.full
SO  - Cancer Res1994 Sep 01; 54
AB  - Genomic instability appears to play an important role in the development, growth, invasiveness, and eventual metastasis of the neoplastic cell. We have used a powerful new technique, comparative genomic hybridization, to evaluate genetic alterations in 10 fresh frozen uveal melanomas. Comparative genomic hybridization utilizes dual fluorescence in situ hybridization to characterize chromosome deletions and duplications, allowing for simultaneous evaluation of the entire human genome. Several consistent chromosomal abnormalities were detected. This study confirmed previous findings obtained using standard cytogenetic techniques but demonstrated an increased incidence in abnormalities of chromosomes 3 and 8; there was loss of chromosome 3 and duplication of 8q. In addition, we identified, although less frequently, other recurrent abnormal regions including alterations on chromosomes 6p, 7q, 9p, and 13q. ©1994 American Association for Cancer Research.