PT  - JOURNAL ARTICLE
AU  - Nakao, Masanobu
AU  - Yamana, Hideaki
AU  - Imai, Yasuhisa
AU  - Toh, Yuji
AU  - Toh, Uhi
AU  - Kimura, Akinori
AU  - Yanoma, Shunsuke
AU  - Kakegawa, Teruo
AU  - Itoh, Kyogo
TI  - HLA A2601-restricted CTLs Recognize a Peptide Antigen Expressed on Squamous Cell Carcinoma
DP  - 1995 Oct 01
TA  - Cancer Research
PG  - 4248--4252
VI  - 55
IP  - 19
4099  - http://cancerres.aacrjournals.org/content/55/19/4248.short
4100  - http://cancerres.aacrjournals.org/content/55/19/4248.full
SO  - Cancer Res1995 Oct 01; 55
AB  - The CD4-CD8+ CTL (KE-4 CTL) cell line against autologous tumor cells was established in a patient with esophageal cancer. This KE-4 CTL recognized a peptide antigen on esophageal and lung squamous cell carcinomas in an HLA A2601-restricted manner, as evaluated by cytotoxicity against a panel of tumor cells, transfection experiments with HLA A2601 cDNA, and reconstitution with eluted peptides. None of the normal cells tested was lysed by this CTL. These results suggest the existence of HLA A2601-restricted CTL precursors recognizing a peptide antigen on SCC in a patient with esophageal cancer. ©1995 American Association for Cancer Research.