PT  - JOURNAL ARTICLE
AU  - Chen, Xinbin
AU  - Bargonetti, Jill
AU  - Prives, Carol
TI  - p53, through p21 (WAF1/CIP1), Induces Cyclin D1 Synthesis
DP  - 1995 Oct 01
TA  - Cancer Research
PG  - 4257--4263
VI  - 55
IP  - 19
4099  - http://cancerres.aacrjournals.org/content/55/19/4257.short
4100  - http://cancerres.aacrjournals.org/content/55/19/4257.full
SO  - Cancer Res1995 Oct 01; 55
AB  - Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein. We show here that accumulation of the wild-type p53 protein in either human or murine cells markedly increases expression of cyclin D1. The induction of cyclin D1 can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin D1 and G1 arrest defines a new cellular response to p53. ©1995 American Association for Cancer Research.