RT Journal Article
SR Electronic
T1 Prevalence of Androgen Receptor Gene Mutations in Latent Prostatic Carcinomas from Japanese Men
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 1621
OP 1624
VO 55
IS 8
A1 Takahashi, Hiroyuki
A1 Furusato, Masakuni
A1 Allsbrook, William C.
A1 Nishii, Hiroshi
A1 Wakui, Shin
A1 Barrett, J. Carl
A1 Boyd, Jeff
YR 1995
UL http://cancerres.aacrjournals.org/content/55/8/1621.abstract
AB The incidence rate of clinically apparent prostatic carcinoma is 8-fold higher in the United States than in Japan, while the prevalence of latent prostatic carcinoma, a presumed precursor to clinical carcinoma, is similar in the two countries. The purpose of this study was to investigate the hypothesis that this profound difference in incidence rates of clinical carcinoma reflects distinct profiles of molecular genetic alterations in the latent precursor lesions that occur in the two countries. A significant fraction of latent carcinomas from Japanese men were found to contain inactivating mutations of the androgen receptor gene, while no such mutations were found in latent carcinomas from American men. No mutations were found in clinical carcinomas from either country. These data offer a potential molecular genetic explanation that may partially account for the distinct prostatic carcinoma incidence rates in these two populations. ©1995 American Association for Cancer Research.