RT Journal Article
SR Electronic
T1 Increased Oxidative DNA Damage in <em>Helicobacter pylori</em>-infected Human Gastric Mucosa
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 1279
OP 1282
VO 56
IS 6
A1 Baik, Seung-Chul
A1 Youn, Hee-Shang
A1 Chung, Myung-Hee
A1 Lee, Woo-Kon
A1 Cho, Myung-Je
A1 Ko, Gyung-Hyuck
A1 Park, Cheol-Keun
A1 Kasai, Hiroshi
A1 Rhee, Kwang-Ho
YR 1996
UL http://cancerres.aacrjournals.org/content/56/6/1279.abstract
AB Helicobacter pylori causes type B gastritis. It shows strong association with the development of gastric carcinoma. A plausible hypothesis for the missing link between H. pylori infection and gastric carcinogenesis involves oxygen free radical-induced DNA damage. To test this hypothesis, we compared the amount of 8-hydroxydeoxyguanosine, a marker for oxygen free radical-induced DNA damage, in the DNA of human gastric mucosa with and without H. pylori infection. Gastric antral biopsies were taken from pediatric patients and volunteers to select H. pylori-positive and H. pylori-negative specimens. The 8-hydroxydeoxyguanosine content of the gastric mucosal DNA was measured after H. pylori-positive and H. pylori-negative volunteers were identified. The increased level of oxidative DNA damage suggests the mechanistic link between H. pylori infection and gastric carcinoma. ©1996 American Association for Cancer Research.