PT  - JOURNAL ARTICLE
AU  - Greenblatt, Marc S.
AU  - Grollman, Arthur P.
AU  - Harris, Curtis C.
TI  - Deletions and Insertions in the <em>p53</em> Tumor Suppressor Gene in Human Cancers: Confirmation of the DNA Polymerase Slippage/Misalignment Model
DP  - 1996 May 01
TA  - Cancer Research
PG  - 2130--2136
VI  - 56
IP  - 9
4099  - http://cancerres.aacrjournals.org/content/56/9/2130.short
4100  - http://cancerres.aacrjournals.org/content/56/9/2130.full
SO  - Cancer Res1996 May 01; 56
AB  - We analyzed all published deletions and insertions in the p53 gene to assess the relevance of mutagenesis models. Almost all deletions and insertions can be explained by one or more of the following DNA sequence features: monotonic base runs, adjacent or nonadjacent repeats of short tandem sequences, palindromes, and runs of purines or pyrimidines (homocopolymer runs). Increased length of monotonic runs correlates positively with increased frequency of events. Complex frameshift mutations can be explained by the formation of quasi-palindromes, with mismatch excision and replication using one strand of the palindrome as a template. Deletions and insertions in the p53 tumor suppressor gene may reflect both spontaneous and carcinogen-induced mutagenesis. ©1996 American Association for Cancer Research.