RT Journal Article
SR Electronic
T1 Genetic Changes in Inherited and Sporadic Ovarian Carcinomas by Comparative Genomic Hybridization: Extensive Similarity Except for a Difference at Chromosome 2q24–q32
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 2715
OP 2719
VO 58
IS 13
A1 Tapper, Johanna
A1 Sarantaus, Laura
A1 Vahteristo, Pia
A1 Nevanlinna, Heli
A1 Hemmer, Samuli
A1 Seppälä, Markku
A1 Knuutila, Sakari
A1 Butzow, Ralf
YR 1998
UL http://cancerres.aacrjournals.org/content/58/13/2715.abstract
AB Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma. Except for loss of the respective wild-type allele, somatic genetic changes needed for the progression of inherited ovarian tumors are unknown. A genome-wide search for such alterations was performed by comparative genomic hybridization analysis on BRCA1 and BRCA2 mutation-positive (n = 20) ovarian carcinoma specimens. Comparison with sporadic ovarian carcinomas (n = 20) revealed extensive genetic similarity between the inherited and sporadic carcinomas with the sole exception of a frequent gain of 2q24–q32 in the inherited group, suggesting the presence of an oncogene at 2q24–q32 operating in the absence of BRCA1 function. The overall similarity of gains and losses by comparative genomic hybridization suggests a common main pathway in tumor progression of both inherited and sporadic ovarian carcinomas. ©1998 American Association for Cancer Research.