PT  - JOURNAL ARTICLE
AU  - Li, Jing
AU  - Simpson, Laura
AU  - Takahashi, Michelle
AU  - Miliaresis, Christa
AU  - Myers, Michael P.
AU  - Tonks, Nicholas
AU  - Parsons, Ramon
TI  - The <em>PTEN/MMAC1</em> Tumor Suppressor Induces Cell Death That Is Rescued by the AKT/Protein Kinase B Oncogene
DP  - 1998 Dec 15
TA  - Cancer Research
PG  - 5667--5672
VI  - 58
IP  - 24
4099  - http://cancerres.aacrjournals.org/content/58/24/5667.short
4100  - http://cancerres.aacrjournals.org/content/58/24/5667.full
SO  - Cancer Res1998 Dec 15; 58
AB  - PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of cancers. PTEN encodes a phosphatase that recognizes phosphoprotein substrates and the phospholipid, phosphatidylinositol-3,4,5-triphosphate. PTEN inhibited cell growth and/or colony formation in all of the epithelial lines tested with one exception. The decrease in cellular proliferation was associated with an induction of apoptosis and an inhibition of signaling through the phosphatidylinositol 3′-kinase pathway. Akt/protein kinase B, a gene whose antiapoptotic function is regulated by phosphatidylinositol-3,4,5-triphosphate, was able to rescue cells from PTEN-dependent death. PTEN, therefore, appears to suppress tumor growth by regulating phosphatidylinositol 3′-kinase signaling.