PT  - JOURNAL ARTICLE
AU  - Bandiera, Antonella
AU  - Bonifacio, Daniela
AU  - Manfioletti, Guidalberto
AU  - Mantovani, Fiamma
AU  - Rustighi, Alessandra
AU  - Zanconati, Fabrizio
AU  - Fusco, Alfredo
AU  - Di Bonito, Luigi
AU  - Giancotti, Vincenzo
TI  - Expression of HMGI(Y) Proteins in Squamous Intraepithelial and Invasive Lesions of the Uterine Cervix
DP  - 1998 Feb 01
TA  - Cancer Research
PG  - 426--431
VI  - 58
IP  - 3
4099  - http://cancerres.aacrjournals.org/content/58/3/426.short
4100  - http://cancerres.aacrjournals.org/content/58/3/426.full
SO  - Cancer Res1998 Feb 01; 58
AB  - The expression of nuclear proteins high mobility group (HMG) I and HMGY was investigated in intraepithelial and invasive lesions of the uterine cervix. Human carcinoma cell lines C-4I, ME-180, and CaSki were used for testing protein expression in neoplastic cells from the cervix. Morphological grading of the dysplasias (CIN 1, CIN 2, and CIN 3) and invasive carcinomas from formalin-fixed paraffin-embedded samples parallels the degree of nuclear immunostaining obtained using a polyclonal antibody raised against the amino-terminal region of HMGI(Y) proteins. The immunostaining obtained with HMGI(Y) antibody was compared with that observed using the antibody Ki-67, and the results were similar. We suggest the use of HMGI(Y) antibody in clinical oncology as a useful marker of intraepithelial lesions and invasive carcinomas. ©1998 American Association for Cancer Research.