RT Journal Article
SR Electronic
T1 Expression of HMGI(Y) Proteins in Squamous Intraepithelial and Invasive Lesions of the Uterine Cervix
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 426
OP 431
VO 58
IS 3
A1 Bandiera, Antonella
A1 Bonifacio, Daniela
A1 Manfioletti, Guidalberto
A1 Mantovani, Fiamma
A1 Rustighi, Alessandra
A1 Zanconati, Fabrizio
A1 Fusco, Alfredo
A1 Di Bonito, Luigi
A1 Giancotti, Vincenzo
YR 1998
UL http://cancerres.aacrjournals.org/content/58/3/426.abstract
AB The expression of nuclear proteins high mobility group (HMG) I and HMGY was investigated in intraepithelial and invasive lesions of the uterine cervix. Human carcinoma cell lines C-4I, ME-180, and CaSki were used for testing protein expression in neoplastic cells from the cervix. Morphological grading of the dysplasias (CIN 1, CIN 2, and CIN 3) and invasive carcinomas from formalin-fixed paraffin-embedded samples parallels the degree of nuclear immunostaining obtained using a polyclonal antibody raised against the amino-terminal region of HMGI(Y) proteins. The immunostaining obtained with HMGI(Y) antibody was compared with that observed using the antibody Ki-67, and the results were similar. We suggest the use of HMGI(Y) antibody in clinical oncology as a useful marker of intraepithelial lesions and invasive carcinomas. ©1998 American Association for Cancer Research.