RT Journal Article
SR Electronic
T1 Dietary Modulation of Carcinoma Development in a Mouse Model for Human Familial Adenomatous Polyposis
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5713
OP 5717
VO 58
IS 24
A1 Yang, Kan
A1 Edelmann, Winfried
A1 Fan, Kunhua
A1 Lau, Kirkland
A1 Leung, Denis
A1 Newmark, Harold
A1 Kucherlapati, Raju
A1 Lipkin, Martin
YR 1998
UL http://cancerres.aacrjournals.org/content/58/24/5713.abstract
AB Familial adenomatous polyposis (FAP) is caused by a dominant mutation in the adenomatous polyposis coli (APC) gene. Individuals with FAP progressively develop adenomas and carcinomas of the colon and rectum. We developed a mouse model for this disorder by genetically modifying the Apc gene. The resulting mice Apc1638 progressively develop neoplasms in the colon and remainder of the gastrointestinal tract. In this study when Apc1638 mice were fed a Western-style diet, they developed an increased incidence of the end point of carcinomas and number of invasive tumors. The findings therefore demonstrated dietary modulation of carcinoma incidence in mice with a targeted mutation providing a model for the study of gene-environment interactions in cancer. ©1998 American Association for Cancer Research.