PT  - JOURNAL ARTICLE
AU  - Daniel, Thomas O.
AU  - Liu, Hua
AU  - Morrow, Jason D.
AU  - Crews, Brenda C.
AU  - Marnett, Lawrence J.
TI  - Thromboxane A<sub>2</sub> Is a Mediator of Cyclooxygenase-2-dependent Endothelial Migration and Angiogenesis
DP  - 1999 Sep 15
TA  - Cancer Research
PG  - 4574--4577
VI  - 59
IP  - 18
4099  - http://cancerres.aacrjournals.org/content/59/18/4574.short
4100  - http://cancerres.aacrjournals.org/content/59/18/4574.full
SO  - Cancer Res1999 Sep 15; 59
AB  - Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of stimuli, suggesting that products of COX-2 may mediate critical steps. Here, we show that thromboxane A2 (TXA2) is one of several eicosanoid products generated by activated human microvascular endothelial cells. Selective COX-2 antagonists inhibit TXA2 production, endothelial migration, and fibroblast growth factor-induced corneal angiogenesis. Endothelial migration and corneal angiogenesis are similarly inhibited by a TXA2 receptor antagonist, SQ29548. A TXA2 agonist, U46619, reconstitutes both migration and angiogenesis responses under COX-2-inhibited conditions. These findings identify TXA2 as a COX-2 product that functions as a critical intermediary of angiogenesis. ©1999 American Association for Cancer Research.