RT Journal Article
SR Electronic
T1 Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6033
OP 6037
VO 59
IS 24
A1 Lew, Young S.
A1 Brown, Stephen L.
A1 Griffin, Robert J.
A1 Song, Chang W.
A1 Kim, Jae Ho
YR 1999
UL http://cancerres.aacrjournals.org/content/59/24/6033.abstract
AB To investigate the antitumor action of arsenic trioxide in solid tumors, we carried out quantitative tumor perfusion studies, using locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c mice. The tumor perfusion studies were assessed by two separate methods: 99mTc clearance and 86Rb uptake. A single administration of arsenic trioxide (10 mg/kg i.p.) produced a preferential vascular shutdown in the tumor tissue at 2 and 6 h, leading to massive necrosis in the central part of the tumor. The phenomenon was repeatable at intervals of weekly administration of the drug in the same tumor. Normal skin, muscle, and kidney were relatively unaffected by arsenic trioxide. These results suggest that the drug may be investigated as an adjunct to the standard cancer therapeutic modalities.