PT  - JOURNAL ARTICLE
AU  - Sweeney, Carol
AU  - McClure, Gail Y.
AU  - Fares, Manal Y.
AU  - Stone, Angie
AU  - Coles, Brian F.
AU  - Thompson, Patricia A.
AU  - Korourian, Soheila
AU  - Hutchins, Laura F.
AU  - Kadlubar, Fred F.
AU  - Ambrosone, Christine B.
TI  - Association between Survival after Treatment for Breast Cancer and Glutathione <em>S</em>-Transferase P1 Ile<sup>105</sup>Val Polymorphism
DP  - 2000 Oct 15
TA  - Cancer Research
PG  - 5621--5624
VI  - 60
IP  - 20
4099  - http://cancerres.aacrjournals.org/content/60/20/5621.short
4100  - http://cancerres.aacrjournals.org/content/60/20/5621.full
SO  - Cancer Res2000 Oct 15; 60
AB  - A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5–1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1–1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.