RT Journal Article
SR Electronic
T1 Association between Survival after Treatment for Breast Cancer and Glutathione <em>S</em>-Transferase P1 Ile<sup>105</sup>Val Polymorphism
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5621
OP 5624
VO 60
IS 20
A1 Sweeney, Carol
A1 McClure, Gail Y.
A1 Fares, Manal Y.
A1 Stone, Angie
A1 Coles, Brian F.
A1 Thompson, Patricia A.
A1 Korourian, Soheila
A1 Hutchins, Laura F.
A1 Kadlubar, Fred F.
A1 Ambrosone, Christine B.
YR 2000
UL http://cancerres.aacrjournals.org/content/60/20/5621.abstract
AB A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5–1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1–1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.