RT Journal Article
SR Electronic
T1 <em>HER-2/neu</em> Promotes Androgen-independent Survival and Growth of Prostate Cancer Cells through the Akt Pathway
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6841
OP 6845
VO 60
IS 24
A1 Wen, Yong
A1 Hu, Mickey C-T.
A1 Makino, Keishi
A1 Spohn, Bill
A1 Bartholomeusz, Geoffrey
A1 Yan, Duen-Hwa
A1 Hung, Mien-Chie
YR 2000
UL http://cancerres.aacrjournals.org/content/60/24/6841.abstract
AB HER-2/neu has been implicated in the activation of androgen receptor (AR) and in inducing hormone-independent prostate cancer growth. Here we report that HER-2/neu activates Akt (protein kinase B) to promote prostate cancer cell survival and growth in the absence of androgen. Blocking of the Akt pathway by a dominant-negative Akt or an inhibitor LY294002 abrogates the HER-2/neu-induced AR signaling and cell survival/growth effects in the absence or presence of androgen. Akt specifically binds to AR and phosphorylates serines 213 and 791 of AR. Thus, Akt is a novel activator of AR required for HER-2/neu signaling to androgen-independent survival and growth of prostate cancer cells.