PT - JOURNAL ARTICLE AU - Magee, Jeffrey A. AU - Araki, Toshiyuki AU - Patil, Sushama AU - Ehrig, Torsten AU - True, Lawrence AU - Humphrey, Peter A. AU - Catalona, William J. AU - Watson, Mark A. AU - Milbrandt, Jeffrey TI - Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer DP - 2001 Aug 01 TA - Cancer Research PG - 5692--5696 VI - 61 IP - 15 4099 - http://cancerres.aacrjournals.org/content/61/15/5692.short 4100 - http://cancerres.aacrjournals.org/content/61/15/5692.full SO - Cancer Res2001 Aug 01; 61 AB - Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that coincide with prostate cancer progression remain enigmatic. We have addressed this problem by characterizing the expression profiles of several benign and malignant human prostate samples, and we have identified several genes that are differentially expressed between benign and malignant glands. One gene that was overexpressed encodes the serine protease hepsin. We used an independent sample set to confirm that hepsin is overexpressed in prostate tumors, and in situ hybridization demonstrates that hepsin is specifically overexpressed in the carcinoma cells themselves. These facts, together with the molecular properties of hepsin, make it an ideal target for prostate cancer therapy. ©2001 American Association for Cancer Research.