RT Journal Article
SR Electronic
T1 Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5692
OP 5696
VO 61
IS 15
A1 Magee, Jeffrey A.
A1 Araki, Toshiyuki
A1 Patil, Sushama
A1 Ehrig, Torsten
A1 True, Lawrence
A1 Humphrey, Peter A.
A1 Catalona, William J.
A1 Watson, Mark A.
A1 Milbrandt, Jeffrey
YR 2001
UL http://cancerres.aacrjournals.org/content/61/15/5692.abstract
AB Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that coincide with prostate cancer progression remain enigmatic. We have addressed this problem by characterizing the expression profiles of several benign and malignant human prostate samples, and we have identified several genes that are differentially expressed between benign and malignant glands. One gene that was overexpressed encodes the serine protease hepsin. We used an independent sample set to confirm that hepsin is overexpressed in prostate tumors, and in situ hybridization demonstrates that hepsin is specifically overexpressed in the carcinoma cells themselves. These facts, together with the molecular properties of hepsin, make it an ideal target for prostate cancer therapy. ©2001 American Association for Cancer Research.