PT  - JOURNAL ARTICLE
AU  - Hao, Xing Pei
AU  - Pretlow, Thomas G.
AU  - Rao, J. Sunil
AU  - Pretlow, Theresa P.
TI  - Inducible Nitric Oxide Synthase (iNOS) Is Expressed Similarly in Multiple Aberrant Crypt Foci and Colorectal Tumors from the Same Patients
DP  - 2001 Jan 01
TA  - Cancer Research
PG  - 419--422
VI  - 61
IP  - 2
4099  - http://cancerres.aacrjournals.org/content/61/2/419.short
4100  - http://cancerres.aacrjournals.org/content/61/2/419.full
SO  - Cancer Res2001 Jan 01; 61
AB  - Aberrant crypt foci (ACF) are the earliest identified neoplastic lesions in the colon. Aberrant expression of inducible nitric oxide synthase (iNOS or NOS2) has been documented in colorectal tumors, but expression of iNOS has not been reported in human ACF or multiple neoplastic lesions from the same patient. Immunohistochemical expression of iNOS was evaluated in 42 ACF, 14 adenomas, and 25 carcinomas and their adjacent normal mucosa. iNOS was strongly expressed in the normal colonic epithelial cells of all patients; it was markedly reduced in 21 of 42 (50%) ACF and in 14 of 25 (56%) carcinomas. The expression of iNOS was remarkably similar in multiple lesions from the same patient (P < 0.0001). These results suggest that the reduced expression of iNOS is a very early event in the development of some human colorectal tumors, and that host factors control the expression of iNOS similarly in premalignant and malignant colonic epithelial cells. ©2001 American Association for Cancer Research.