PT  - JOURNAL ARTICLE
AU  - Achanzar, William E.
AU  - Diwan, Bhalchandra A.
AU  - Liu, Jie
AU  - Quader, Salmaan T.
AU  - Webber, Mukta M.
AU  - Waalkes, Michael P.
TI  - Cadmium-induced Malignant Transformation of Human Prostate Epithelial Cells
DP  - 2001 Jan 01
TA  - Cancer Research
PG  - 455--458
VI  - 61
IP  - 2
4099  - http://cancerres.aacrjournals.org/content/61/2/455.short
4100  - http://cancerres.aacrjournals.org/content/61/2/455.full
SO  - Cancer Res2001 Jan 01; 61
AB  - Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in vitro and rapidly formed highly invasive and occasionally metastatic adenocarcinomas upon inoculation into mice. The transformed cells also showed increased secretion of MMP-2 and MMP-9, a phenomenon observed in human prostate tumors and linked to aggressive behavior. Cadmium-induced malignant transformation of human prostate epithelial cells strongly fortifies the evidence for a potential role of cadmium in prostate cancer. ©2001 American Association for Cancer Research.