PT  - JOURNAL ARTICLE
AU  - Tsavaler, Larisa
AU  - Shapero, Michael H.
AU  - Morkowski, Stan
AU  - Laus, Reiner
TI  - <em>Trp-p8</em>, a Novel Prostate-specific Gene, Is Up-Regulated in Prostate Cancer and Other Malignancies and Shares High Homology with Transient Receptor Potential Calcium Channel Proteins
DP  - 2001 May 01
TA  - Cancer Research
PG  - 3760--3769
VI  - 61
IP  - 9
4099  - http://cancerres.aacrjournals.org/content/61/9/3760.short
4100  - http://cancerres.aacrjournals.org/content/61/9/3760.full
SO  - Cancer Res2001 May 01; 61
AB  - We have identified and cloned a novel gene, trp-p8, by screening a prostate-specific subtracted cDNA library. The 5694-bp cDNA has a 3312-bp open reading frame, which codes for a 1104 amino acid putative protein with seven transmembrane domains. The predicted protein revealed significant homology with the transient receptor potential (trp) family of Ca2+ channel proteins. Northern blot analysis indicated that trp-p8 expression within normal human tissues is mostly restricted to prostate epithelial cells. In situ hybridization analysis showed that trp-p8 mRNA expression was at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, trp-p8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding trp-p8 were hardly detected or not detected in the corresponding normal human tissues. ©2001 American Association for Cancer Research.