RT Journal Article SR Electronic T1 3-Deoxy-3-[18F]Fluorothymidine-Positron Emission Tomography for Noninvasive Assessment of Proliferation in Pulmonary Nodules JF Cancer Research JO Cancer Res FD American Association for Cancer Research SP 3331 OP 3334 VO 62 IS 12 A1 Buck, Andreas K. A1 Schirrmeister, Holger A1 Hetzel, Martin A1 von der Heide, Mareike A1 Halter, Gisela A1 Glatting, Gerhard A1 Mattfeldt, Torsten A1 Liewald, Florian A1 Reske, Sven N. A1 Neumaier, Bernd YR 2002 UL http://cancerres.aacrjournals.org/content/62/12/3331.abstract AB We investigated whether uptake of the thymidine analogue 3-deoxy-3-[18F]fluorothymidine ([18F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs). Thirty patients with SPNs were prospectively examined with positron emission tomography. Standardized uptake values were calculated for quantification of FLT uptake. Histopathology revealed 22 malignant and 8 benign lesions. Proliferation was evaluated by Ki-67 immunostaining and showed a mean proliferation fraction of 30.9% (range, 1–65%) in malignant SPNs and <5% in benign lesions. Linear regression analysis indicated a significant correlation between FLT-standardized uptake values and proliferative activity (P < 0.0001; r = 0.87). FLT uptake was specific for malignant lesions and may be used for differential diagnosis of SPNs, assessment of proliferation, and estimation of prognosis. ©2002 American Association for Cancer Research.