PT  - JOURNAL ARTICLE
AU  - Lal, Anita
AU  - Glazer, Chad A.
AU  - Martinson, Holly M.
AU  - Friedman, Henry S.
AU  - Archer, Gary E.
AU  - Sampson, John H.
AU  - Riggins, Gregory J.
TI  - Mutant Epidermal Growth Factor Receptor Up-Regulates Molecular Effectors of Tumor Invasion
DP  - 2002 Jun 15
TA  - Cancer Research
PG  - 3335--3339
VI  - 62
IP  - 12
4099  - http://cancerres.aacrjournals.org/content/62/12/3335.short
4100  - http://cancerres.aacrjournals.org/content/62/12/3335.full
SO  - Cancer Res2002 Jun 15; 62
AB  - The gene most commonly altered in human glioblastomas is the epidermalgrowth factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively down-regulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion. ©2002 American Association for Cancer Research.