PT  - JOURNAL ARTICLE
AU  - Zou, Yiyu
AU  - Peng, Hua
AU  - Zhou, Binhua
AU  - Wen, Yong
AU  - Wang, Shao-Chun
AU  - Tsai, Eing-Mei
AU  - Hung, Mien-Chie
TI  - Systemic Tumor Suppression by the Proapoptotic Gene <strong><em>bik</em></strong>
DP  - 2002 Jan 01
TA  - Cancer Research
PG  - 8--12
VI  - 62
IP  - 1
4099  - http://cancerres.aacrjournals.org/content/62/1/8.short
4100  - http://cancerres.aacrjournals.org/content/62/1/8.full
SO  - Cancer Res2002 Jan 01; 62
AB  - Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5–10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer. ©2002 American Association for Cancer Research.