PT  - JOURNAL ARTICLE
AU  - Mendoza, Nerissa
AU  - Phillips, Gail Lewis
AU  - Silva, Johnny
AU  - Schwall, Ralph
AU  - Wickramasinghe, Dineli
TI  - Inhibition of Ligand-mediated HER2 Activation in Androgen-independent Prostate Cancer
DP  - 2002 Oct 01
TA  - Cancer Research
PG  - 5485--5488
VI  - 62
IP  - 19
4099  - http://cancerres.aacrjournals.org/content/62/19/5485.short
4100  - http://cancerres.aacrjournals.org/content/62/19/5485.full
SO  - Cancer Res2002 Oct 01; 62
AB  - Hormone-independent tumor growth and metastasis are associated with increased mortality in human prostate cancer. In this study, we evaluate a potential role for ligand-mediated activation of HER2 receptor tyrosine kinase in androgen-independent prostate cancers. HER2, HER3, and epidermal growth factor receptor were detected in the androgen-independent cell line 22Rv1. Heregulin stimulation results in receptor phosphorylation and cell proliferation that is inhibited by increasing concentrations of anti-HER2 recombinant humanized monoclonal antibody (rhuMAb) 2C4. Furthermore, inhibition of tumor growth was observed in xenografts derived from 22Rv1 cells when treated with rhuMAb 2C4 in a dose-dependent manner. These studies provide a framework, both in vitro and in vivo, to examine the molecular mechanisms of ligand-driven HER2 activation in androgen-independent tumorigenesis. ©2002 American Association for Cancer Research.