RT Journal Article
SR Electronic
T1 Absence of the <strong><em>CD44</em></strong> Gene Prevents Sarcoma Metastasis
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 2281
OP 2286
VO 62
IS 8
A1 Weber, Georg F.
A1 Bronson, Roderick T.
A1 Ilagan, John
A1 Cantor, Harvey
A1 Schmits, Rudolf
A1 Mak, Tak W.
YR 2002
UL http://cancerres.aacrjournals.org/content/62/8/2281.abstract
AB To test the role of the CD44 gene in tumorigenesis, mice with the min mutationof the APC gene or with the tm1 mutation of the p53 gene were crossedwith CD44 knockout mice. The absence of CD44 gene products did not affect tumor incidence or survival; however, mice with disruption of the CD44 gene showed virtually aborted metastasis formation of osteosarcomas. This is in agreement with the role attributed to CD44 variants in the spread of cancer. Therefore, CD44 gene products are not essential for tumor incidence and growth but are important in regulating metastasis formation. ©2002 American Association for Cancer Research.