RT Journal Article SR Electronic T1 A Critical Requirement of Interferon γ-mediated Angiostasis for Tumor Rejection by CD8+ T Cells JF Cancer Research JO Cancer Res FD American Association for Cancer Research SP 4095 OP 4100 VO 63 IS 14 A1 Qin, Zhihai A1 Schwartzkopff, Johannes A1 Pradera, Felicia A1 Kammertœns, Thomas A1 Seliger, Barbara A1 Pircher, Hanspeter A1 Blankenstein, Thomas YR 2003 UL http://cancerres.aacrjournals.org/content/63/14/4095.abstract AB It is thought that tumor rejection by CD8+ T-cell effectors is primarily mediated by direct killing. We show that rejection of different tumors (fibrosarcoma, ras-transformed fibroblasts, colon carcinoma, and plasmacytoma) by CD8+ T cells is always preceded by inhibition of tumor-induced angiogenesis. Angiostasis and tumor rejection were observed in perforin but not in IFN-γ-deficient mice. Furthermore, adoptive transfer of tumor-specific CD8+ T cells from IFN-γ-competent mice inhibited angiogenesis of lung metastases in comparison to those from IFN-γ gene-deficient mice. Taken together with our previous findings, we conclude that IFN-γ-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4+ and CD8+ T-cell effectors.