PT  - JOURNAL ARTICLE
AU  - Strome, Scott E.
AU  - Dong, Haidong
AU  - Tamura, Hideto
AU  - Voss, Stephen G.
AU  - Flies, Dallas B.
AU  - Tamada, Koji
AU  - Salomao, Diva
AU  - Cheville, John
AU  - Hirano, Fumiya
AU  - Lin, Wei
AU  - Kasperbauer, Jan L.
AU  - Ballman, Karla V.
AU  - Chen, Lieping
TI  - B7-H1 Blockade Augments Adoptive T-Cell Immunotherapy for Squamous Cell Carcinoma
DP  - 2003 Oct 01
TA  - Cancer Research
PG  - 6501--6505
VI  - 63
IP  - 19
4099  - http://cancerres.aacrjournals.org/content/63/19/6501.short
4100  - http://cancerres.aacrjournals.org/content/63/19/6501.full
SO  - Cancer Res2003 Oct 01; 63
AB  - In this report, we demonstrate that B7-H1, a B7 family molecule implicated in tumor immune evasion, is constitutively expressed on 66% of freshly isolated squamous cell carcinomas of the head and neck (SCCHN). To define the potential impact of tumor-associated B7-H1 on immunotherapy, the B7-H1-negative mouse SCC line, SCCVII, was transfected to express B7-H1. Although all of the animals succumbed to B7-H1/SCCVII tumors even after adoptive T-cell immunotherapy, the infusion of B7-H1 blocking monoclonal antibody with activated T cells cured 60% of animals. These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy. ©2003 American Association for Cancer Research.