RT Journal Article
SR Electronic
T1 <strong><em>In Vivo</em></strong> Flow Cytometry
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5044
OP 5047
DO 10.1158/0008-5472.CAN-04-1058
VO 64
IS 15
A1 Georgakoudi, Irene
A1 Solban, Nicolas
A1 Novak, John
A1 Rice, William L.
A1 Wei, Xunbin
A1 Hasan, Tayyaba
A1 Lin, Charles P.
YR 2004
UL http://cancerres.aacrjournals.org/content/64/15/5044.abstract
AB The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cell lines with different metastatic potential in mice and rats. We find that the cell line and the host environment affect the circulation kinetics of prostate cancer cells, with the intrinsic cell line properties determining the initial rate of cell depletion from the circulation and the host affecting cell circulation at later time points.