PT  - JOURNAL ARTICLE
AU  - Xiong, Wei
AU  - Zeng, Zhao Yang
AU  - Xia, Jia Hui
AU  - Xia, Kun
AU  - Shen, Shou Rong
AU  - Li, Xiao Ling
AU  - Hu, Dong Xu
AU  - Tan, Chen
AU  - Xiang, Juan Juan
AU  - Zhou, Jie
AU  - Deng, Hao
AU  - Fan, Song Qing
AU  - Li, Wei Fang
AU  - Wang, Rong
AU  - Zhou, Ming
AU  - Zhu, Shi Guo
AU  - Lü, Hong Bin
AU  - Qian, Jun
AU  - Zhang, Bi Cheng
AU  - Wang, Jie Ru
AU  - Ma, Jian
AU  - Xiao, Bing Yi
AU  - Huang, He
AU  - Zhang, Qiu Hong
AU  - Zhou, Yan Hong
AU  - Luo, Xiao Min
AU  - De Zhou, Hou
AU  - Yang, Yi Xin
AU  - Dai, He Ping
AU  - Feng, Guo Yin
AU  - Pan, Qian
AU  - Wu, Ling Qian
AU  - He, Lin
AU  - Li, Gui Yuan
TI  - A Susceptibility Locus at Chromosome 3p21 Linked to Familial Nasopharyngeal Carcinoma
AID  - 10.1158/0008-5472.CAN-03-3253
DP  - 2004 Mar 15
TA  - Cancer Research
PG  - 1972--1974
VI  - 64
IP  - 6
4099  - http://cancerres.aacrjournals.org/content/64/6/1972.short
4100  - http://cancerres.aacrjournals.org/content/64/6/1972.full
SO  - Cancer Res2004 Mar 15; 64
AB  - Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed. ©2004 American Association for Cancer Research.