PT  - JOURNAL ARTICLE
AU  - Lillard-Wetherell, Kate
AU  - Combs, Kelly A.
AU  - Groden, Joanna
TI  - BLM Helicase Complements Disrupted Type II Telomere Lengthening in Telomerase-Negative <em>sgs1</em> Yeast
AID  - 10.1158/0008-5472.CAN-05-0632
DP  - 2005 Jul 01
TA  - Cancer Research
PG  - 5520--5522
VI  - 65
IP  - 13
4099  - http://cancerres.aacrjournals.org/content/65/13/5520.short
4100  - http://cancerres.aacrjournals.org/content/65/13/5520.full
SO  - Cancer Res2005 Jul 01; 65
AB  - Recombination-mediated pathways for telomere lengthening may be utilized in the absence of telomerase activity. The RecQ-like helicases, BLM and Sgs1, are implicated in recombination-mediated telomere lengthening in human cells and budding yeast, respectively. Here, we show that BLM expression rescues disrupted telomere lengthening in telomerase-negative sgs1 yeast. BLM helicase activity is required for this complementation, indicating BLM and Sgs1 resolve the same telomeric structures. These data support a conserved function for BLM and Sgs1 in recombination-mediated telomere lengthening. ©2005 American Association for Cancer Research.