PT  - JOURNAL ARTICLE
AU  - Matzke, Alexandra
AU  - Herrlich, Peter
AU  - Ponta, Helmut
AU  - Orian-Rousseau, Véronique
TI  - A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration
AID  - 10.1158/0008-5472.CAN-05-0207
DP  - 2005 Jul 15
TA  - Cancer Research
PG  - 6105--6110
VI  - 65
IP  - 14
4099  - http://cancerres.aacrjournals.org/content/65/14/6105.short
4100  - http://cancerres.aacrjournals.org/content/65/14/6105.full
SO  - Cancer Res2005 Jul 15; 65
AB  - Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration. ©2005 American Association for Cancer Research.