RT Journal Article
SR Electronic
T1 A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 6105
OP 6110
DO 10.1158/0008-5472.CAN-05-0207
VO 65
IS 14
A1 Matzke, Alexandra
A1 Herrlich, Peter
A1 Ponta, Helmut
A1 Orian-Rousseau, Véronique
YR 2005
UL http://cancerres.aacrjournals.org/content/65/14/6105.abstract
AB Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration. ©2005 American Association for Cancer Research.