RT Journal Article
SR Electronic
T1 High-resolution Global Genomic Survey of 178 Gliomas Reveals Novel Regions of Copy Number Alteration and Allelic Imbalances
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 9428
OP 9436
DO 10.1158/0008-5472.CAN-06-1691
VO 66
IS 19
A1 Kotliarov, Yuri
A1 Steed, Mary Ellen
A1 Christopher, Neil
A1 Walling, Jennifer
A1 Su, Qin
A1 Center, Angela
A1 Heiss, John
A1 Rosenblum, Mark
A1 Mikkelsen, Tom
A1 Zenklusen, Jean C.
A1 Fine, Howard A.
YR 2006
UL http://cancerres.aacrjournals.org/content/66/19/9428.abstract
AB Primary brain tumors are the fourth leading cause of cancer mortality in adults under the age of 54 years and the leading cause of cancer mortality in children in the United States. Therapy for the most common type of primary brain tumors, gliomas, remains suboptimal. The development of new and more effective treatments will likely require a better understanding of the biology of these tumors. Here, we show that use of the high-density 100K single-nucleotide polymorphism arrays in a large number of primary tumor samples allows for a much higher resolution survey of the glioma genome than has been previously reported in any tumor type. We not only confirmed alterations in genomic areas previously reported to be affected in gliomas, but we also refined the location of those sites and uncovered multiple, previously unknown regions that are affected by copy number alterations (amplifications, homozygous and heterozygous deletions) as well as allelic imbalances (loss of heterozygosity/gene conversions). The wealth of genomic data produced may allow for the development of a more rational molecular classification of gliomas and serve as an important starting point in the search for new molecular therapeutic targets. (Cancer Res 2006; 66(19): 9428-36) ©2006 American Association for Cancer Research.