RT Journal Article
SR Electronic
T1 Plasma Folate, Vitamin B<sub>6</sub>, Vitamin B<sub>12</sub>, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 5553
OP 5560
DO 10.1158/0008-5472.CAN-06-4463
VO 67
IS 11
A1 Schernhammer, Eva
A1 Wolpin, Brian
A1 Rifai, Nader
A1 Cochrane, Barbara
A1 Manson, Jo Ann
A1 Ma, Jing
A1 Giovannucci, Ed
A1 Thomson, Cynthia
A1 Stampfer, Meir J.
A1 Fuchs, Charles
YR 2007
UL http://cancerres.aacrjournals.org/content/67/11/5553.abstract
AB Folate deficiency induces DNA breaks and may alter cellular capacity for mutation and epigenetic methylation. Few studies have examined the influence of one-carbon nutrients on pancreatic cancer risk, although recent studies suggest a potential protective effect for one-carbon nutrients from food sources, but not from supplements. We conducted a prospective nested case-control study to examine plasma concentrations of folate, vitamin B6 [whose main circulating form is pyridoxal-5′-phosphate (PLP)], vitamin B12, and homocysteine in relationship to pancreatic cancer, using four large prospective cohorts. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using conditional logistic regression. All statistical tests were two sided. Among 208 cases and 623 controls, we observed no association between folate, PLP, vitamin B12, or homocysteine and pancreatic cancer risk. Comparing the highest to lowest quartiles of plasma concentration, the ORs were 1.20 (95% CI, 0.76–1.91) for folate, 0.80 (95% CI, 0.51–1.25) for B6, 0.91 (95% CI, 0.57–1.46) for B12, and 1.43 (95% CI, 0.90–2.28) for homocysteine. In analyses restricted to nonusers of multivitamins, we observe a modest inverse trend between folate, PLP, and B12 and pancreatic cancer risk. In contrast, no such inverse associations were observed among study subjects who reported multivitamin supplement use. Among all participants, plasma levels of folate, B6, B12, and homocysteine were not associated with a significant reduction in the risk of pancreatic cancer. Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk. [Cancer Res 2007;67(11):5553–60] ©2007 American Association for Cancer Research.