PT  - JOURNAL ARTICLE
AU  - Gilbertson, Richard J.
AU  - Gutmann, David H.
TI  - Tumorigenesis in the Brain: Location, Location, Location
AID  - 10.1158/0008-5472.CAN-07-0760
DP  - 2007 Jun 15
TA  - Cancer Research
PG  - 5579--5582
VI  - 67
IP  - 12
4099  - http://cancerres.aacrjournals.org/content/67/12/5579.short
4100  - http://cancerres.aacrjournals.org/content/67/12/5579.full
SO  - Cancer Res2007 Jun 15; 67
AB  - Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties (“cancer stem cells”). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors. [Cancer Res 2007;67(12):5579–82] ©2007 American Association for Cancer Research.